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Above the researchers designed a novel graft polymer shell for iron oxide nanoparticles that can deliver anticancer drugs and enable real-time monitoring of drug release.
According to a report from the Physicist Organization Network on October 30 (Beijing time), recently, a New Scientist from the University of New South Wales, Australia (UNSW) has synthesized a novel type of iron oxide nanoparticles that can not only deliver anticancer drugs to cells but also drugs. Release can be monitored in real time. The researchers said that this is an important advance in the field of nanodiagnostics and treatment. The related papers were published in the recently published American Chemical Society journal ACS Nano.
"This type of iron oxide nanoparticles can track drug delivery and provide the possibility to adapt to individual differences in different patients," said Cyril Boya, associate professor of the School of Chemical Engineering at UNSW. Knowing how the nanoparticle delivered by the anticancer drug is released and its effect on the cells and surrounding tissues, the doctor can adjust the dose to achieve the best therapeutic effect of the drug.
Magnetic iron oxide nanoparticles (IONPs) have been widely studied for a long time, but most of them are used as contrast agents in magnetic resonance imaging (MRI). Until recently, it began to explore their use for drug delivery. At present, only a few studies have described how to load chemotherapeutic drugs on the surfaces of magnetic iron oxide nanoparticles. They have not yet proved effectively that they can deliver drugs to the inside of cells. In this study, we designed a new method to load drugs on the surface of IONPs and demonstrated for the first time that these particles can deliver drugs into the cells.
The UNSW researchers installed IONPs with a well-designed graft polymer shell that gave excellent gel stability in both water and serum. The polymer shell enables reversible adhesion of doxorubicin (DOX), an antitumor drug, through the imine bond, providing a controlled release mechanism for DOX in an acidic environment.
Using a technique called "Fluorescence Lifetime Imaging Microscopy" (FLIM), researchers demonstrated for the first time that IONPs can be easily accepted by two cell lines (MCF-7 breast cancer cells and H1299 lung cancer cells) while being monitored Release of DOX in cells.
"Usually, drug release experiments are only simulated in the laboratory, not in cells. This is very important. With cells we can determine the dynamics of drug release in a real biological environment." Workbench chemistry (traditional chemical experiments that do not use high-end equipment and computer models) can also be performed in cells, and the next step is to enter living applications.†(Reporter Chang Lijun)
Yangzhou Chengde have the certification of API 5L and API 5CT, so we permit to produce and sell the API pipes with the Chengde brand directly.
We can produce the API pipes according to the API 5L standard, such as the GR.B steel pipe, X42 steel pipe, X52 steel pipe, X65 steel pipe, X70 steel pipe, X80 steel pipe, etc.
The follow table is our main reference list on the API 5L product
|
Customer |
PJT name |
Grade and size range |
Quantity(MT) |
|
Keppel |
N/A |
X52/X65 PSL2 OD (244.5~457)x(12.7~38.1) mm |
3650 |
|
Shell |
NYHAMNA |
X52/GR6/X52 PSL2 OD (219~609)x(12.7~65) mm |
968 |
|
SBM |
SAXI BATUQUE |
X52/X65 PSL2 OD (219~660)x(25.4~70) mm |
1100 |
|
Exxon Mobil |
Oil Field Chayvo |
X60PSL2/GR.6 OD(273.1~609.6)x(15.09~76.2) |
310 |
|
Dalian Shipping Building/ZPMC |
Leg bracing pipe |
X52~X80 PSL2 OD (159~955) x(10~51)mm |
7050 |
|
PETROBRAS |
PMXL1 MEXILHAO |
X52/X60/X65 PSL2 OD (219~762)x(18.3~69.85)mm |
850 |
The Piercing and rolling technology of Chengde possesses a number of patents in designing and manufacturing the equipment, and has improved in lots of areas targeting better performance and efficiency, which has distinguished itself from the peers.
Advantages of our pipes
1 Uniform mechanical properties and dimensions in longitudinal& transversal directions and better surface condition
2 Minimum Order Quantity (MOQ) as low as ONE piece AND Huge size scope to accommodate the project requirements (8"~48``).
3 Competitive price and shorter delivery, Superior international standard quality.
4 30 years experience and approvals with Major EPCs/OEMs/Clients in the supplier chain.
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