According to a report from the Physicist Organization Network on March 28 (Beijing time), scientists at the University of Georgia in the United States have discovered that using nanoparticles and alternating magnetic fields can kill cancerous tumor cells located in the head and neck of mice within half an hour. Without damaging healthy cells and tissues. The relevant research report was published in the recently published Journal of Therapeutic Diagnostics.
Zhao Qun, an assistant professor of physics at the Franklin Institute of the Arts, the lead author of the study, said that they can use small amounts of concentrated magnetic iron oxide nanoparticles to kill cancer cells. This treatment can easily destroy epithelial cancerous tumor cells, which marks the first time researchers can use magnetic iron oxide nanoparticles to induce hyperthermia and hyperthermia in laboratory mice.
Researchers around the world are exploring the use of heated nanoparticles as a potential cancer treatment. Previous studies have also demonstrated that combining magnetic iron oxide nanoparticles with strong alternating currents can generate high temperatures sufficient to kill tumor cells. Zhao Qun said that the results of this study are optimistic, but he also said that in the future before considering human clinical trials, the test for larger animals needs to be completed.
During the experiment, the researchers added about 0.5 ml of magnetic iron oxide nanoparticles solution to the tumor site. As the mice gradually relaxed under anesthesia, they placed it in a plastic tube wrapped in a coil outside. This device can generate alternating magnetic fields up to 100,000 times per second. The magnetic field will only heat the concentrated nanoparticles within the cancerous tumor without damaging the surrounding healthy cells and tissues.
Magnetic iron oxide nanoparticles can effectively increase the contrast of magnetic resonance imaging at the site of the tumor, which means that even if physicists could not visually identify cancer through magnetic resonance imaging scans, nanoparticles can help them detect cancer. Researchers hope to use a single reagent or medium for diagnosis and treatment in the future, which is why they are very interested in using magnetic nanoparticles.
Zhao Qun said that when cancer cells experience a high temperature environment, they will be more sensitive to drugs. This study will pave the way for other studies aimed at combating cancer by using biodegradable nanoparticle materials such as magnetic iron oxide, such as carrying and transporting anticancer drugs directly to tumor sites. (Reporter Zhang Hao)
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